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KMID : 1098420170250060404
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Korean Journal of Medicinal Crop Science
2017 Volume.25 No. 6 p.404 ~ p.410
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Cell Viability and Hair Growth Effect on 3T3-L1 Cells of Ethanol Extract from Calendula officinalis L. Flower, Phellinus linteus Fruit Body and Houttuynia cordata Thunb. Whole Plant
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Jin Seong-Woo
Koh Young-Woo
Yun Kyeong-Won
Kim Kyeong-Je
Je Hae-Shin
Im Seung-Bin
Kim Kwang-Sang
Yu Byung-Jo
Seo Kyoung-Sun
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Abstract
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Background: Hair loss related syndromes are increasing due to environmental pollution and stress. Hair care products are mainly prepared by mixing chemicals and natural extracts, such as those obtained from medicinal plants. The purpose of this study was to investigate the effects of 70% ethanol extracts from the flowers of Calendula officinalis, fruit body of Phellinus linteus, and the whole plant of Houttuynia cordata on the growth of CCD-986 cells, hair follicle dermal papilla cells (HFDPC), and 3T3-L1 cells.
Methods and Results: All sample extracts at all concentrations, except for that from P. linteus fruit body at 500μg/ml, were cytotoxic to CCD-986 cells. However, none of the sample extracts were cytotoxic to HFDPC. The lipid differentiation of 3T3-L1 cells regulates hair regeneration via secretion of platelet derived growth factor. The 70% ethanol extract of H. cordata whole plant promoted hair growth. Adipogenesis rate significantly increased in a treatment concentration-dependent manner.
Conclusions: These results suggest that 70% ethanol extracts of C. officinalis flower, P. linteus fruit body and H. cordata could be used for the development of hair care products.
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KEYWORD
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Calendula officinalis, Houttuynia cordata, Phellinus linteus, Adipocyte, Hair Growth Effect
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